Savina A.A., Zemlyanova E.V. Assessment of Potential Years of Life Lost in Women of Reproductive Age. City Healthсare. 2025;6(4-2):254-263. https: ... Savina A.A., Zemlyanova E.V. Assessment of Potential Years of Life Lost in Women of Reproductive Age. City Healthсare. 2025;6(4-2):254-263. https://doi.org/10.47619/2713-2617.zm.2025.v.6i4-2;254-263ISSN 2713-2617DOI 10.47619/2713-2617.zm.2025.v.6i4-2;254-263РИНЦ: https://elibrary.ru/item.asp?id=88813847Posted on site: 26.01.26 AbstractAs the largest Russian megalopolis, Moscow has its own demographic characteristics due to high population density, fast pace of life, environmental issues, and significant migration burden. In the context of modern challenges characterized by a birth rate decline, population aging and an increase inmorbidity, the analysis of potential years of life lost is particularly relevant, especially among women of reproductive age (15-49 years). The purpose of this study was to identify the main causes of death in women of reproductive age and to assess their contribution to potential years of life lost in Moscow. Materials andmethods. In this study, the Rosstat statistical data were used. Standardized mortality rates and average life expectancy were calculated. The results of the study show a decreasing trend in the population groups aged 15-49 against the background of the general population growth in Moscow. There is an increase in mortality in population groups aged 15-19 and 40-44. Unlike other parts of Russia, where cardiovascular diseases are the leading cause of death, in Moscow the majority of cases are presented by neoplasms (26% of cases). The calculation of the average life expectancy in women of reproductive age who died from various causes showed that they could have lived for about 50 more years, which underlines the importance of reducing mortality in this group. In particular, neoplasms and diseases of the circulatory system are the crucial factors affectingthe years of potential life lost, which requires attention from the healthcare system and the development of targeted programs. Conclusion. The results indicate the need to strengthen preventive measures, especially in relation to cancer and external causes of death